Description
Structure & Identity
PT-141 is a cyclic heptapeptide, meaning its seven-amino-acid chain is joined into a ring rather than left as a straight line. That ring shape locks the molecule into a stable form and is a big part of why it holds onto its melanocortin receptor targets. It is a close chemical relative of the melanocortin agonist family, but its cyclic structure sets it apart from the linear peptides in that group.
Research Background
PT-141 research centers on the melanocortin receptors, particularly MC3R and MC4R, and on what happens when those receptors are switched on.
- Melanocortin agonist. PT-141 is characterized as a non-selective agonist across melanocortin receptors [PMID: 31429064].
- Receptor system. The central melanocortin system it engages is an active target in metabolic and neurological research [PMID: 37365323].
- Cellular model. Recent work examined bremelanotide’s melanocortin-receptor activity in a cultured-cell viability assay [PMID: 39197897].
- Compound overview. Review profiles summarize its melanocortin pharmacology [PMID: 34436837].
These are laboratory research contexts. The material carries no approved use and is intended only for that kind of study.
Specifications
| Attribute | Value |
| Chemical name | Bremelanotide (PT-141) |
| Also Known As | Bremelanotide, PT-141 |
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.2 g/mol |
| Structure | Cyclic heptapeptide |
| Purity | ≥99% by reverse-phase HPLC |
| Length | Cyclic 7 amino acids |
| Identity | Confirmed by ESI mass spectrometry |
| Physical form | Lyophilized powder |
| Appearance | White to off-white solid |
| Quantity | 10 mg per vial |
| Storage | -20°C, protected from light |
| Solubility | Soluble in bacteriostatic or sterile water |
| Classification | Research use only |
Storage & Handling
Keep the sealed vial frozen at -20°C and protected from light until you need it. After preparation, the solution should be refrigerated at 2-8°C and used in research within roughly two weeks. Bringing a cold vial up to room temperature before opening limits condensation, and minimizing freeze-thaw cycles helps the cyclic peptide stay intact.
Quality Assurance
PT-141 is produced under research-grade manufacturing controls and passes independent testing before it is released. Purity comes from reverse-phase HPLC and identity from mass spectrometry, performed by third-party laboratories, including Janoshik Analytical and domestic US labs, rather than in-house only. The certificate of analysis is matched to each batch, so its purity and identity figures apply to your specific vial.
Frequently Asked Questions
What is PT-141?
PT-141, or Bremelanotide, is a cyclic seven-amino-acid peptide that activates melanocortin receptors. It is studied in laboratory research on melanocortin signaling and is supplied for research use only.
Is PT-141 the same as bremelanotide?
Yes. “PT-141” is the research name and “Bremelanotide” is the chemical/drug name for the same molecule.
Which receptors does PT-141 act on?
It acts as a non-selective agonist across several melanocortin receptors, with reported activity at MC1R, MC3R, and MC4R. That broad action is what makes it useful for studying the melanocortin system.
How is PT-141 related to Melanotan 2?
Both come from melanocortin research and both are agonists at melanocortin receptors, but they are different molecules with different structures. PT-141 is cyclic; Melanotan 2 is a different melanocortin analog.
Is PT-141 FDA approved?
The bremelanotide molecule is approved as a drug in a specific clinical context, but the material sold here is a research-use-only reference peptide, not for human or veterinary use.
What is PT-141’s molecular weight?
Its molecular formula is C50H68N14O10 and its molecular weight is about 1025.2 g/mol, with CAS number 189691-06-3.
How should PT-141 be stored?
Store the dry powder at -20°C, protected from light. After reconstitution for research, keep it at 2-8°C and use within about two weeks.
How is the quality of this PT-141 verified?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch comes with its own certificate of analysis.
