CAS: 189691-06-3 · MW: 1025.2 Da · Purity: ≥99% by reverse-phase HPLC · Format: 10 mg powder · Identity: ESI-MS confirmed
PT-141, known chemically as Bremelanotide, is a peptide that acts on the melanocortin system, a set of receptors involved in everything from pigmentation to appetite to sexual signaling. It grew out of research on an earlier tanning peptide and was redirected toward melanocortin signaling in the nervous system. Each vial contains 10 mg of freeze-dried powder, supplied as a reference compound for melanocortin-receptor research.
Structure & Identity
PT-141 is a cyclic heptapeptide, meaning its seven-amino-acid chain is joined into a ring rather than left as a straight line. That ring shape locks the molecule into a stable form and is a big part of why it holds onto its melanocortin receptor targets. It is a close chemical relative of the melanocortin agonist family, but its cyclic structure sets it apart from the linear peptides in that group.
Research Background
PT-141 research centers on the melanocortin receptors, particularly MC3R and MC4R, and on what happens when those receptors are switched on.
- Melanocortin agonist. PT-141 is characterized as a non-selective agonist across melanocortin receptors [PMID: 31429064].
- Receptor system. The central melanocortin system it engages is an active target in metabolic and neurological research [PMID: 37365323].
- Cellular model. More recent work examined bremelanotide’s melanocortin-receptor activity in cancer-cell research [PMID: 39197897].
- Compound overview. Review profiles summarize its melanocortin pharmacology [PMID: 34436837].
These are laboratory research contexts. The material carries no approved use and is intended only for that kind of study.
Specifications
| Attribute |
Value |
| Chemical name |
Bremelanotide (PT-141) |
| Also Known As |
Bremelanotide, PT-141 |
| CAS number |
189691-06-3 |
| Molecular formula |
C50H68N14O10 |
| Molecular weight |
1025.2 g/mol |
| Structure |
Cyclic heptapeptide |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
Cyclic 7 amino acids |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
10 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water |
| Classification |
Research use only |
Storage & Handling
Keep the sealed vial frozen at -20°C and protected from light until you need it. After reconstitution, the solution should be refrigerated at 2-8°C and used within roughly two weeks. Bringing a cold vial up to room temperature before opening limits condensation, and minimizing freeze-thaw cycles helps the cyclic peptide stay intact.
Storage and Handling Guide
Quality Assurance
PT-141 is produced under research-grade manufacturing controls and passes independent testing before it is released. Purity comes from reverse-phase HPLC and identity from mass spectrometry, performed by third-party laboratories, including Janoshik Analytical and domestic US labs, rather than in-house only. The certificate of analysis is matched to each batch, so its purity and identity figures apply to your specific vial.
Quality & Testing
Frequently Asked Questions
What is PT-141?
PT-141, or Bremelanotide, is a cyclic seven-amino-acid peptide that activates melanocortin receptors. It is studied in laboratory research on melanocortin signaling and is supplied for research use only.
Is PT-141 the same as bremelanotide?
Yes. “PT-141” is the research name and “Bremelanotide” is the chemical/drug name for the same molecule.
Which receptors does PT-141 act on?
It acts as a non-selective agonist across several melanocortin receptors, with reported activity at MC1R, MC3R, and MC4R. That broad action is what makes it useful for studying the melanocortin system.
How is PT-141 related to Melanotan 2?
Both come from melanocortin research and both are agonists at melanocortin receptors, but they are different molecules with different structures. PT-141 is cyclic; Melanotan 2 is a different melanocortin analog.
Is PT-141 FDA approved?
The bremelanotide molecule is approved as a drug in a specific clinical context, but the material sold here is a research-use-only reference peptide, not for human or veterinary use.
What is PT-141’s molecular weight?
Its molecular formula is C50H68N14O10 and its molecular weight is about 1025.2 g/mol, with CAS number 189691-06-3.
How should PT-141 be stored?
Store the dry powder at -20°C, protected from light. After reconstitution for research, keep it at 2-8°C and use within about two weeks.
How is the quality of this PT-141 verified?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch has its own published certificate of analysis.
References
- Bremelanotide: First Approval. 2019. PMID: 31429064.
- Targeting the central melanocortin system for the treatment of metabolic disorders. 2023. PMID: 37365323.
- Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma. 2024. PMID: 39197897.
