CAS: 910463-68-2 · MW: 4113.6 Da · Purity: ≥99% by reverse-phase HPLC · Format: 10 mg powder · Identity: ESI-MS confirmed
This is the 10 mg vial of GLP-1 (Sema), a long-acting analog of the gut hormone GLP-1. The mid-range vial suits research that works through a moderate amount of material. Chemically it is identical to the other sizes: a GLP-1 receptor agonist engineered to resist breakdown and stay active far longer than the natural hormone, studied across metabolic and incretin research.
Structure & Identity
GLP-1 (Sema) is a GLP-1 analog assembled on the human GLP-1 sequence, with targeted amino-acid substitutions and a fatty-acid side chain joined through a short linker. The substitutions block the clearing enzyme that shortens natural GLP-1’s life, while the fatty-acid chain anchors the peptide to albumin in circulation. Those two features are what make it a durable, GLP-1-like research tool.
Research Background
Work with GLP-1 (Sema) explores the GLP-1 receptor and the wider signaling it triggers.
- Receptor activation. Acting at the GLP-1 receptor, GLP-1 (Sema) is a standard tool for studying receptor pharmacology, framed by detailed physiology research [1].
- Broader metabolic mechanisms. GLP-1 signaling influences more than glucose handling, and its mechanisms have been examined in metabolic models [2].
- Immune-signaling angle. The anti-inflammatory properties of GLP-1 receptor agonists give researchers a second line of study [3].
These describe research areas rather than approved applications, and the peptide is supplied for that laboratory work.
Specifications
| Attribute |
Value |
| Chemical name |
GLP-1 (Sema) |
| Also Known As |
(GLP-1 receptor agonist) |
| CAS number |
910463-68-2 |
| Molecular formula |
C187H291N45O59 |
| Molecular weight |
4113.6 g/mol |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
31 amino acids (modified) |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
10 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water (gentle mixing) |
| Classification |
Research use only |
Storage & Handling
Store the unopened vial at -20°C, away from light, until needed. Once dissolved, keep the solution at 2-8°C and use it within roughly two weeks. Given the peptide’s size and the mid-range quantity here, let the vial reach room temperature before opening and plan aliquots so the stock is not repeatedly frozen and thawed.
Storage and Handling Guide
Quality Assurance
Every lot of GLP-1 (Sema) clears independent quality control before release. Manufacturing follows research-grade standards, and purity by reverse-phase HPLC and identity by mass spectrometry are confirmed by outside laboratories, including Janoshik Analytical and US-based labs. A batch-matched certificate of analysis is published for the batch so the data traces to your material.
Quality & Testing
Frequently Asked Questions
What is GLP-1 (Sema) used for in research?
It is studied in research on the GLP-1 receptor and incretin signaling. GLP-1 (Sema) is a research-use-only material with no approved human use in this setting.
Is the 10 mg the same molecule as the 5 mg and 15 mg?
Yes, only the amount of peptide differs. The 10 mg size sits between the two for research that needs a moderate working stock.
How does GLP-1 (Sema) act on the GLP-1 receptor?
It binds and activates the GLP-1 receptor much like the natural hormone, but its engineered structure keeps it active far longer, which makes it useful for studying sustained receptor signaling.
What sets GLP-1 (Sema) apart from GLP-2 (Tirz)?
GLP-1 (Sema) targets the single GLP-1 receptor, while GLP-2 (Tirz) is a dual agonist that also targets the GIP receptor. The number of receptors each one hits is the core difference.
Is GLP-1 (Sema) FDA approved?
The molecule is approved as a drug in specific clinical uses, but this listing is a research-use-only reference peptide and is not for human or veterinary use.
What is its molecular weight and CAS number?
GLP-1 (Sema) has a molecular weight around 4113.6 g/mol, the formula C187H291N45O59, and CAS number 910463-68-2.
How should the 10 mg vial be handled?
Keep it frozen at -20°C and out of light. After reconstitution for research, refrigerate at 2-8°C, use within about two weeks, and avoid repeated freeze-thaw cycles.
How pure is this GLP-1 (Sema)?
It is supplied at ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation from an independent lab, and a certificate of analysis comes with each batch.
Why does GLP-1 (Sema) need careful reconstitution?
Its large, modified structure dissolves best with gentle handling. Swirling rather than shaking and giving it time to go into solution helps keep the peptide intact.
References
- GLP-1 physiology informs the pharmacotherapy of obesity. 2022. PMID: 34626851.
- GLP-1-based medications: Mechanisms involved in obesity treatment. 2025. PMID: 40466247.
- The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists. 2022. PMID: 35738455.
