CAS: 33515-09-2 · MW: 1182.3 Da · Purity: ≥99% by reverse-phase HPLC · Format: 2 mg powder · Identity: ESI-MS confirmed
Gonadorelin is the lab-made copy of a hormone the body already makes: gonadotropin-releasing hormone, or GnRH. The brain uses this signal to tell the pituitary to release the hormones that run the reproductive system. Each vial holds 2 mg of freeze-dried powder. It is a common reference peptide in endocrinology research because it sits right at the top of that signaling cascade.
Structure & Identity
Gonadorelin is a decapeptide, a chain of ten amino acids: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Its sequence is identical to natural GnRH, which is what makes it a faithful research stand-in for the real hormone. The pyroglutamate (pGlu) start and amidated end are the natural caps that GnRH itself carries.
Research Background
Because gonadorelin matches native GnRH exactly, most research treats it as the hormone itself and studies the machinery downstream of it.
- Identity. Gonadorelin is synthetic gonadotropin-releasing hormone (GnRH), identical in sequence to the natural hormone [PMID: 6358816].
- Pituitary signaling. GnRH drives the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH); animal work has used gonadorelin to probe that LH response [PMID: 9291531].
- Reproductive-axis mapping. GnRH-like signaling has been characterized across reproductive tissues [PMID: 3378068].
- Antagonist research. The GnRH system has also been studied through antagonist development [PMID: 15822867].
- Analytical work. Analytical methods for small peptide hormones like gonadorelin support consistent identification [PMID: 36858006].
These are research contexts, not approved uses. The peptide is provided to support laboratory study of the reproductive signaling axis.
Specifications
| Attribute |
Value |
| Chemical name |
Gonadorelin (GnRH) |
| Also Known As |
GnRH, LH-RH, luliberin |
| Sequence |
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
| CAS number |
33515-09-2 |
| Molecular formula |
C55H75N17O13 |
| Molecular weight |
1182.3 g/mol |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
10 amino acids |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
2 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water |
| Classification |
Research use only |
Storage & Handling
Store the unopened vial frozen at -20°C, away from light. Once you have reconstituted it, keep the solution refrigerated at 2-8°C and use it within about two weeks, because the dissolved peptide is more fragile than the powder. Allowing a chilled vial to reach room temperature before opening helps avoid condensation, and repeated freeze-thaw cycles are best avoided.
Storage and Handling Guide
Quality Assurance
Gonadorelin is produced to research-grade manufacturing standards and is verified by an independent lab before it ships. Its purity is determined by reverse-phase HPLC and its identity by mass spectrometry, with testing carried out by third-party laboratories such as Janoshik Analytical alongside domestic US labs. Each batch has its own certificate of analysis, so you can confirm the results against the exact vial in hand.
Quality & Testing
Frequently Asked Questions
What is gonadorelin?
Gonadorelin is a synthetic peptide identical to gonadotropin-releasing hormone (GnRH), the brain signal that tells the pituitary to release reproductive hormones. It is studied in endocrinology research and supplied for research use only.
What is the difference between gonadorelin and GnRH?
There is no chemical difference in the sequence, gonadorelin is the manufactured form of GnRH. “Gonadorelin” is simply the name used for the synthetic peptide supplied for laboratory work.
What does gonadorelin do in research models?
In models, GnRH signaling prompts the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Researchers use gonadorelin to study that release and the reproductive signaling axis it sits above.
How many amino acids does gonadorelin have?
Ten. It is a decapeptide with the sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, a molecular weight near 1182.3 g/mol, and CAS number 33515-09-2.
Is gonadorelin FDA approved?
Gonadorelin exists as an approved medicine in some clinical contexts, but the material sold here is a research-use-only reference peptide, not for human or veterinary use, diagnosis, or treatment.
How should gonadorelin be stored?
Keep the dry powder frozen at -20°C and protected from light. After reconstitution for research, store it at 2-8°C and use within roughly two weeks.
Why is this vial 2 mg rather than 10 mg?
Gonadorelin is a potent signaling peptide typically studied at small quantities, so it is offered in a 2 mg vial. The amount refers to the gonadorelin peptide content.
How is quality verified?
Purity is confirmed at ≥99% by reverse-phase HPLC and identity by mass spectrometry through independent third-party labs, and every batch has a published certificate of analysis.
References
- Effect of gonadoreline and naloxone on induction of ovulation and plasma LH. 1997. PMID: 9291531.
- GnRH-like proteins in cows: concentrations during corpora lutea development. 1988. PMID: 3378068.
- GnRH-like factors in the rat testis and human seminal plasma. 1984. PMID: 6100021.
