CAS: 62304-98-7 · MW: 3108.3 Da · Purity: ≥99% by reverse-phase HPLC · Format: 10 mg powder · Identity: ESI-MS confirmed
Thymosin Alpha-1 is a peptide the body derives from a larger protein made in the thymus, the gland that trains the immune system. That origin is the key to its research profile: it sits squarely in immune-signaling studies. Each vial holds 10 mg of freeze-dried powder. Among research peptides it is one of the most established immune-focused subjects, with a literature stretching back decades.
Structure & Identity
Thymosin Alpha-1 is a 28-amino-acid peptide with an acetylated N-terminus, cleaved from the larger precursor prothymosin alpha. The acetyl cap at its front end is a natural modification carried over from how the body produces it. Its longer chain, relative to the small signaling peptides, reflects the fuller immune-signaling role researchers study.
Research Background
Thymosin Alpha-1 research is centered firmly on the immune system.
- Thymic origin. Thymosin Alpha-1 is cleaved from prothymosin alpha, produced in the immune-training thymus gland [PMID: 11381492].
- Immune modulation. It is widely studied for influencing immune-cell signaling [PMID: 27450734].
- Comprehensive characterization. Detailed reviews map its immune roles across research settings [PMID: 33362999].
- Oncology-adjacent immunity. It appears in cancer-related immune-regulation research [PMID: 36812669].
- Antiviral immune research. It has been examined in HIV-1 and hepatitis-B research contexts [PMID: 28106477].
These are laboratory research areas rather than approved uses, and the material is provided to support that immune-focused study.
Specifications
| Attribute |
Value |
| Chemical name |
Thymosin Alpha-1 (acetylated, 28-mer) |
| Also Known As |
Tα1, thymalfasin |
| CAS number |
62304-98-7 |
| Molecular formula |
C129H215N33O55 |
| Molecular weight |
3108.3 g/mol |
| Modification |
N-terminal acetylation |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
28 amino acids (acetylated) |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
10 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water |
| Classification |
Research use only |
Storage & Handling
Keep the unopened vial in a -20°C freezer, protected from light, until you use it. After reconstitution, store the solution at 2-8°C and use it within about two weeks. As with other longer peptides, bringing the vial to room temperature before opening and minimizing freeze-thaw cycles both help keep the 28-residue chain intact.
Storage and Handling Guide
Quality Assurance
Thymosin Alpha-1 is manufactured under research-grade controls and released only after independent verification. Reverse-phase HPLC quantifies its purity and mass spectrometry confirms its identity, with testing done by third-party laboratories, including Janoshik Analytical and domestic US labs. Each batch has its own published certificate of analysis, tying the results to the material you receive.
Quality & Testing
Frequently Asked Questions
What is Thymosin Alpha-1?
Thymosin Alpha-1 is a 28-amino-acid peptide derived from a thymus protein, studied mainly in immune-signaling research. It is supplied for research use only.
Where does Thymosin Alpha-1 come from?
It is cleaved from a larger precursor called prothymosin alpha, which is produced in the thymus gland. The thymus is central to immune development, which is why the peptide is an immune-research subject.
What does the acetylation mean?
The peptide carries an acetyl group on its N-terminus, a small natural modification present in the way the body makes it. It is reflected in the “acetylated” descriptor on the specifications.
How does Thymosin Alpha-1 work in research?
Research describes it as an immune-modulating peptide that influences immune-cell signaling. These are findings from laboratory and model systems, not human treatment outcomes.
Is Thymosin Alpha-1 FDA approved?
The thymosin alpha-1 molecule is used clinically in some countries, but the material sold here is a research-use-only reference peptide, not for human or veterinary use.
What is its molecular weight?
It is a 28-residue peptide with a molecular formula of C129H215N33O55 and a molecular weight around 3108.3 g/mol, CAS number 62304-98-7.
How should Thymosin Alpha-1 be stored?
Store the powder frozen at -20°C and protected from light. Once reconstituted for research, keep it at 2-8°C and use within about two weeks.
How is quality confirmed?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch has a published certificate of analysis.
References
- Thymosin alpha-1. 2001. PMID: 11381492.
- Immune Modulation with Thymosin Alpha 1 Treatment. 2016. PMID: 27450734.
- Thymosin alpha 1: A comprehensive review of the literature. 2020. PMID: 33362999.
