CAS: 62568-57-4 · MW: 848.8 Da · Purity: ≥99% by reverse-phase HPLC · Format: 5 mg powder · Identity: ESI-MS confirmed
DSIP, short for delta sleep-inducing peptide, is one of the older curiosities in peptide research. It was first pulled out of brain tissue decades ago because it seemed to encourage the slow, “delta” brain waves that mark deep sleep. Each vial holds 5 mg of freeze-dried powder. Researchers keep coming back to it because, even after all this time, exactly how it works remains an open question worth studying.
Structure & Identity
DSIP is a nonapeptide, nine amino acids in the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It is a small, unmodified chain, which is part of why it has been so hard to pin down: it does not carry the obvious structural handles that make some peptides easy to trace to a single receptor. That open-ended quality is exactly what keeps it in the literature.
Research Background
DSIP research spans decades, and the peptide is still described in reviews as an unresolved puzzle rather than a solved mechanism.
- Origin. DSIP was first isolated for its apparent link to slow, delta-wave brain activity in deep sleep [PMID: 265572].
- Unresolved mechanism. Decades of reviews still describe it as an incompletely understood peptide [PMID: 3550726].
- Ongoing questions. Later syntheses continue to treat DSIP as an open research puzzle [PMID: 16539679].
- Neurological model. It has been studied in a rat focal-stroke model for effects on motor recovery [PMID: 34500605].
- Memory research. A phosphorylated form has been examined for spatial memory and p-CREB expression [PMID: 30107169].
None of this is an approved use. The peptide is supplied to support continued laboratory research into its biology.
Specifications
| Attribute |
Value |
| Chemical name |
Delta sleep-inducing peptide (DSIP) |
| Sequence |
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| CAS number |
62568-57-4 |
| Molecular formula |
C35H48N10O15 (confirm) |
| Molecular weight |
848.8 g/mol |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
9 amino acids |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
5 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water |
| Classification |
Research use only |
Storage & Handling
The dry vial should sit in a -20°C freezer, out of direct light, until you use it. Once dissolved, DSIP belongs at 2-8°C and should be used within about two weeks. Letting a frozen vial warm to room temperature before opening cuts down on moisture getting in, and it is worth planning aliquots so the material is not frozen and thawed over and over.
Storage and Handling Guide
Quality Assurance
DSIP is manufactured under research-grade controls and checked by an outside laboratory before release. Reverse-phase HPLC establishes its purity and mass spectrometry confirms its identity, with the testing performed by independent third-party labs, including Janoshik Analytical and domestic US facilities. A batch-specific certificate of analysis is published for each batch so the numbers can be matched to the material you receive.
Quality & Testing
Frequently Asked Questions
What is DSIP?
DSIP (delta sleep-inducing peptide) is a naturally occurring nine-amino-acid peptide first isolated from brain tissue for its apparent link to deep-sleep brain waves. It is studied in sleep and neurological research and is supplied for research use only.
What does the name “delta sleep-inducing” refer to?
“Delta” refers to the slow delta brain waves seen in deep sleep. The peptide got its name from early experiments that connected it to that delta activity, though its exact mechanism is still under study.
How does DSIP work?
Honestly, that is still an open research question. Decades of reviews describe DSIP as incompletely understood, which is part of why it remains an active subject rather than a settled one. Any mechanism discussion here reflects research models, not human effects.
What is DSIP’s sequence?
It is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, a nonapeptide with CAS number 62568-57-4 and a molecular weight near 848.8 g/mol.
Is DSIP FDA approved?
No, DSIP is not an FDA-approved drug or supplement. It is a research-use-only material and is not intended for human or veterinary use.
Is DSIP related to melatonin?
No, they are different kinds of molecules. Melatonin is a small hormone, while DSIP is a peptide. They are sometimes discussed together only because both appear in sleep research.
How should DSIP be stored?
Keep the powder frozen at -20°C, shielded from light. After reconstitution for research, store the solution at 2-8°C and use it within about two weeks.
How do I know this DSIP is genuine?
Each batch is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and it has a published batch-matched certificate of analysis you can check against your vial.
References
- Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. 1977. PMID: 265572.
- Delta-sleep-inducing peptide (DSIP): an update. 1986. PMID: 3550726.
- Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. 2021. PMID: 34500605.
