CAS: 910463-68-2 · MW: 4113.6 Da · Purity: ≥99% by reverse-phase HPLC · Format: 5 mg powder · Identity: ESI-MS confirmed
GLP-1 (Sema) is the best-known member of a peptide family that mimics GLP-1, a gut hormone the body releases after eating. By copying GLP-1 and resisting quick breakdown, it lets researchers study that hormone’s signaling over a longer, steadier window. This is the 5 mg vial, a size suited to smaller-scale or early-stage work. It is a standard reference peptide in metabolic and incretin research.
Structure & Identity
GLP-1 (Sema) is a modified GLP-1 analog, built on the human GLP-1 backbone with amino-acid substitutions and a fatty-acid chain attached through a linker. Those changes are deliberate: the substitutions protect it from the enzyme that normally clears GLP-1, and the fatty-acid tail lets it bind albumin in the blood, which extends how long it stays active. The result is a peptide that behaves like GLP-1 but lasts far longer in an experiment.
Research Background
GLP-1 (Sema) research is built around the GLP-1 receptor and the metabolic signaling it drives.
- GLP-1 mimic. GLP-1 is a modified GLP-1 analog engineered to resist breakdown and stay active far longer than natural GLP-1 [PMID: 34626851].
- Receptor pharmacology. As a GLP-1 receptor agonist it is a standard tool for receptor-signaling research [PMID: 34626851].
- Metabolic mechanisms. Studies examine the broader mechanisms GLP-1 signaling recruits [PMID: 40466247].
- Anti-inflammatory signaling. The immunological and anti-inflammatory properties of GLP-1 agonists are an active area [PMID: 35738455].
- Organ models. GLP-1 agonists have been studied in diabetic-kidney-injury models [PMID: 39630101].
These are research contexts. GLP-1 (Sema) carries no approved use in this setting, and the material is intended purely for laboratory study.
Specifications
| Attribute |
Value |
| Chemical name |
GLP-1 (Sema) |
| Also Known As |
(GLP-1 receptor agonist) |
| CAS number |
910463-68-2 |
| Molecular formula |
C187H291N45O59 |
| Molecular weight |
4113.6 g/mol |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
31 amino acids (modified) |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
5 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water (gentle mixing) |
| Classification |
Research use only |
Storage & Handling
Keep the sealed vial frozen at -20°C and shielded from light until you use it. After reconstitution, store the solution at 2-8°C and use it within about two weeks. Because GLP-1 (Sema) is a larger, modified peptide, it is worth warming the vial to room temperature before opening and avoiding repeated freeze-thaw cycles, both of which help preserve the intact molecule.
Storage and Handling Guide
Quality Assurance
GLP-1 (Sema) is produced under research-grade manufacturing controls and released only after an outside lab has verified it. Purity is measured by reverse-phase HPLC and identity by mass spectrometry, with that testing carried out by independent third-party laboratories, including Janoshik Analytical and domestic US labs. The certificate of analysis is specific to each batch, so its figures match the vial you receive.
Quality & Testing
Frequently Asked Questions
What is GLP-1 (Sema)?
GLP-1 (Sema) is a synthetic GLP-1 receptor agonist peptide, a modified copy of the gut hormone GLP-1. It is studied in metabolic and incretin research and is supplied for research use only.
What does “GLP-1 receptor agonist” mean?
GLP-1 is a hormone that binds and activates the GLP-1 receptor. An agonist is a molecule that switches that receptor on, so GLP-1 (Sema) acts on the receptor the way natural GLP-1 does, just for longer.
Why does GLP-1 (Sema) last longer than natural GLP-1?
Two design features: amino-acid substitutions that shield it from the enzyme (DPP-4) that clears GLP-1, and a fatty-acid chain that binds albumin in blood to slow its removal. Together these greatly extend its active window.
How is GLP-1 (Sema) different from GLP-2 (Tirz)?
GLP-1 (Sema) acts on one receptor, the GLP-1 receptor. GLP-2 (Tirz) acts on two, the GIP and GLP-1 receptors. That difference in receptor targets is the main thing that sets the two apart in research.
Is GLP-1 (Sema) FDA approved?
The GLP-1 (Sema) molecule is approved as a drug in defined clinical uses, but the material sold here is a research-use-only reference peptide, not for human or veterinary use.
What is GLP-1 (Sema)’s molecular weight?
Its molecular formula is C187H291N45O59 and its molecular weight is about 4113.6 g/mol, with CAS number 910463-68-2.
Why choose the 5 mg size?
The 5 mg vial suits smaller-scale or exploratory research where less material is needed. The amount refers to the GLP-1 (Sema) peptide content.
How should GLP-1 (Sema) be stored?
Keep the powder frozen at -20°C and protected from light. Once reconstituted for research, store the solution at 2-8°C and use within about two weeks.
How is this GLP-1 (Sema) verified?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch has its own published certificate of analysis.
References
- GLP-1 physiology informs the pharmacotherapy of obesity. 2022. PMID: 34626851.
- GLP-1-based medications: Mechanisms involved in obesity treatment. 2025. PMID: 40466247.
- The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists. 2022. PMID: 35738455.
