Description
Structure & Identity
Semaglutide is a modified GLP-1 analog, built on the human GLP-1 backbone with amino-acid substitutions and a fatty-acid chain attached through a linker. Those changes are deliberate: the substitutions protect it from the enzyme that normally clears GLP-1, and the fatty-acid tail lets it bind albumin in the blood, which extends how long it stays active. The result is a peptide that behaves like GLP-1 but lasts far longer in an experiment.
Research Background
Semaglutide research is built around the GLP-1 receptor and the metabolic signaling it drives.
- GLP-1 mimic. Semaglutide is a modified GLP-1 analog engineered to resist breakdown and stay active far longer than natural GLP-1 [PMID: 34626851].
- Receptor pharmacology. As a GLP-1 receptor agonist it is a standard tool for receptor-signaling research [PMID: 34626851].
- Metabolic mechanisms. Studies examine the broader mechanisms GLP-1 signaling recruits [PMID: 40466247].
- Anti-inflammatory signaling. The immunological and anti-inflammatory properties of GLP-1 agonists are an active area [PMID: 35738455].
- Organ models. GLP-1 agonists have been studied in diabetic-kidney-injury models [PMID: 39630101].
These are research contexts. Semaglutide carries no approved use in this setting, and the material is intended purely for laboratory study.
Specifications
| Attribute | Value |
| Chemical name | Semaglutide |
| Also Known As | (GLP-1 receptor agonist) |
| CAS number | 910463-68-2 |
| Molecular formula | C187H291N45O59 |
| Molecular weight | 4113.6 g/mol |
| Purity | ≥99% by reverse-phase HPLC |
| Length | 31 amino acids (modified) |
| Identity | Confirmed by ESI mass spectrometry |
| Physical form | Lyophilized powder |
| Appearance | White to off-white solid |
| Quantity | 5 mg per vial |
| Storage | -20°C, protected from light |
| Solubility | Soluble in bacteriostatic or sterile water (gentle mixing) |
| Classification | Research use only |
Storage & Handling
Keep the sealed vial frozen at -20°C and shielded from light until you use it. After reconstitution, store the solution at 2-8°C and use it within about two weeks. Because Semaglutide is a larger, modified peptide, it is worth warming the vial to room temperature before opening and avoiding repeated freeze-thaw cycles, both of which help preserve the intact molecule.
Quality Assurance
Semaglutide is produced under research-grade manufacturing controls and released only after an outside lab has verified it. Purity is measured by reverse-phase HPLC and identity by mass spectrometry, with that testing carried out by independent third-party laboratories, including Janoshik Analytical and domestic US labs. The certificate of analysis is specific to each batch, so its figures match the vial you receive.
Frequently Asked Questions
What is Semaglutide?
Semaglutide is a synthetic GLP-1 receptor agonist peptide, a modified copy of the gut hormone GLP-1. It is studied in metabolic and incretin research and is supplied for research use only.
What does “GLP-1 receptor agonist” mean?
GLP-1 is a hormone that binds and activates the GLP-1 receptor. An agonist is a molecule that switches that receptor on, so Semaglutide acts on the receptor the way natural GLP-1 does, just for longer.
Why does Semaglutide last longer than natural GLP-1?
Two design features: amino-acid substitutions that shield it from the enzyme (DPP-4) that clears GLP-1, and a fatty-acid chain that binds albumin in blood to slow its removal. Together these greatly extend its active window.
How is Semaglutide different from Tirzepatide?
Semaglutide acts on one receptor, the GLP-1 receptor. Tirzepatide acts on two, the GIP and GLP-1 receptors. That difference in receptor targets is the main thing that sets the two apart in research.
Is Semaglutide FDA approved?
The Semaglutide molecule is approved as a drug in defined clinical uses, but the material sold here is a research-use-only reference peptide, not for human or veterinary use.
What is Semaglutide’s molecular weight?
Its molecular formula is C187H291N45O59 and its molecular weight is about 4113.6 g/mol, with CAS number 910463-68-2.
Why choose the 5 mg size?
The 5 mg vial suits smaller-scale or exploratory research where less material is needed. The amount refers to the Semaglutide peptide content.
How should Semaglutide be stored?
Keep the powder frozen at -20°C and protected from light. Once reconstituted for research, store the solution at 2-8°C and use within about two weeks.
How is this Semaglutide verified?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch ships with its own certificate of analysis.
