CAS: 1415456-99-3 · MW: ~3752 Da · Purity: ≥99% by reverse-phase HPLC · Format: 5 mg powder · Identity: ESI-MS confirmed
Cagrilintide works through a different hormone than the GLP-1 family: amylin. Amylin is released alongside insulin and plays its own role in metabolic signaling. Cagrilintide is a long-acting, lab-engineered amylin analog, built to keep that signaling going far longer than natural amylin would. This is the 5 mg vial, supplied for amylin-receptor and metabolic research.
Structure & Identity
Cagrilintide is a synthetic amylin analog, an acylated peptide designed for a long duration of action. Natural amylin is prone to clumping and is cleared quickly; cagrilintide’s modifications are meant to solve both problems, giving a stable, long-acting research tool. It acts as an agonist at amylin and calcitonin receptors, the receptor family amylin signals through.
Research Background
Cagrilintide research centers on amylin signaling and its metabolic role.
- Amylin analog. Cagrilintide is a long-acting analog of the hormone amylin, engineered to resist aggregation and clearance [PMID: 34288673].
- Receptor target. It acts as an agonist at amylin and calcitonin receptors [PMID: 34288673].
- Combination research. It has been studied alongside semaglutide, pairing amylin and GLP-1 signaling [PMID: 37364590].
- Amylin class. Broader work frames where it sits among amylin analogs in metabolic research [PMID: 39317404].
- Pharmacology. Its PK/PD has been examined in concomitant-administration studies [PMID: 33894838].
These are research contexts, not approved uses, and the peptide is intended for laboratory study.
Specifications
| Attribute |
Value |
| Chemical name |
Cagrilintide (long-acting amylin analog) |
| Also Known As |
AM833 (amylin analog) |
| CAS number |
1415456-99-3 |
| Molecular weight |
~3752 g/mol (confirm) |
| Receptor target |
Amylin / calcitonin receptors |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
~37 amino acids (acylated amylin analog) |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
5 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water (gentle mixing; aggregation-prone) |
| Classification |
Research use only |
Storage & Handling
Store the sealed vial frozen at -20°C and shielded from light until use. After reconstitution, keep the solution refrigerated at 2-8°C and use it within about two weeks. Because amylin-type peptides can be prone to aggregation, gentle reconstitution, warming the vial to room temperature before opening, and avoiding repeated freeze-thaw cycles all help keep the material in good shape.
Storage and Handling Guide
Quality Assurance
Cagrilintide is produced under research-grade manufacturing controls and released only after independent verification. Purity is measured by reverse-phase HPLC and identity by mass spectrometry, with that work done by third-party laboratories such as Janoshik Analytical along with domestic US labs. A certificate of analysis is issued for each batch, so the results trace to the exact vial you receive.
Quality & Testing
Frequently Asked Questions
What is cagrilintide?
Cagrilintide is a synthetic, long-acting analog of the hormone amylin. It is studied in amylin-receptor and metabolic research and is supplied for research use only.
How is cagrilintide different from GLP-1 peptides like GLP-1 (Sema)?
They work through different hormones. GLP-1 (Sema) is a GLP-1 receptor agonist; cagrilintide is an amylin analog acting at amylin/calcitonin receptors. Researchers study them together because the two pathways complement each other.
What is amylin?
Amylin is a hormone the pancreas releases with insulin. It has its own role in metabolic signaling, and cagrilintide is designed to mimic it in a longer-lasting form.
Why is cagrilintide “long-acting”?
Natural amylin is cleared quickly and tends to aggregate. Cagrilintide’s acylated design is meant to resist both, so it stays active far longer, which makes it more practical as a research tool.
Is cagrilintide FDA approved?
No. Cagrilintide is an investigational compound and is not FDA approved. The material here is a research-use-only reference peptide, not for human or veterinary use.
Why are the CAS and molecular weight marked “confirm”?
Cagrilintide is a newer peptide, and different sources report different registry values for it. We flag those fields so they are verified before publishing.
How should cagrilintide be stored?
Keep the powder frozen at -20°C and protected from light. Once reconstituted for research, store at 2-8°C and use within about two weeks.
How is this cagrilintide verified?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch ships with a certificate of analysis.
References
- Development of Cagrilintide, a Long-Acting Amylin Analogue. 2021. PMID: 34288673.
- Efficacy and safety of co-administered once-weekly cagrilintide with once-weekly GLP-1 (Sema). 2023. PMID: 37364590.
- Amylin analogs for the treatment of obesity without diabetes: present and future. 2024. PMID: 39317404.
