Description
Structure & Identity
GLP-1 (Sema) is a GLP-1 analog assembled on the human GLP-1 sequence, with targeted amino-acid substitutions and a fatty-acid side chain joined through a short linker. The substitutions block the clearing enzyme that shortens natural GLP-1’s life, while the fatty-acid chain anchors the peptide to albumin in circulation. Those two features are what make it a durable, GLP-1-like research tool.
Research Background
Work with GLP-1 (Sema) explores the GLP-1 receptor and the wider signaling it triggers.
- Receptor activation. Acting at the GLP-1 receptor, GLP-1 (Sema) is a standard tool for studying receptor pharmacology, framed by detailed physiology research [1].
- Broader metabolic mechanisms. GLP-1 signaling influences more than glucose handling, and its mechanisms have been examined in metabolic models [2].
- Immune-signaling angle. The anti-inflammatory properties of GLP-1 receptor agonists give researchers a second line of study [3].
These describe research areas rather than approved applications, and the peptide is supplied for that laboratory work.
Specifications
| Attribute | Value |
| Chemical name | GLP-1 (Sema) |
| Also Known As | (GLP-1 receptor agonist) |
| CAS number | 910463-68-2 |
| Molecular formula | C187H291N45O59 |
| Molecular weight | 4113.6 g/mol |
| Purity | ≥99% by reverse-phase HPLC |
| Length | 31 amino acids (modified) |
| Identity | Confirmed by ESI mass spectrometry |
| Physical form | Lyophilized powder |
| Appearance | White to off-white solid |
| Quantity | 10 mg per vial |
| Storage | -20°C, protected from light |
| Solubility | Soluble in bacteriostatic or sterile water (gentle mixing) |
| Classification | Research use only |
Storage & Handling
Store the unopened vial at -20°C, away from light, until needed. Once dissolved, keep the solution at 2-8°C and use it within roughly two weeks. Given the peptide’s size and the mid-range quantity here, let the vial reach room temperature before opening and plan aliquots so the stock is not repeatedly frozen and thawed.
Quality Assurance
Every lot of GLP-1 (Sema) clears independent quality control before release. Manufacturing follows research-grade standards, and purity by reverse-phase HPLC and identity by mass spectrometry are confirmed by outside laboratories, including Janoshik Analytical and US-based labs. A batch-matched certificate of analysis is published for the batch so the data traces to your material.
Frequently Asked Questions
What is GLP-1 (Sema) used for in research?
It is studied in research on the GLP-1 receptor and incretin signaling. GLP-1 (Sema) is a research-use-only material with no approved human use in this setting.
Is the 10 mg the same molecule as the 5 mg and 15 mg?
Yes, only the amount of peptide differs. The 10 mg size sits between the two for research that needs a moderate working stock.
How does GLP-1 (Sema) act on the GLP-1 receptor?
It binds and activates the GLP-1 receptor much like the natural hormone, but its engineered structure keeps it active far longer, which makes it useful for studying sustained receptor signaling.
What sets GLP-1 (Sema) apart from GLP-2 (Tirz)?
GLP-1 (Sema) targets the single GLP-1 receptor, while GLP-2 (Tirz) is a dual agonist that also targets the GIP receptor. The number of receptors each one hits is the core difference.
Is GLP-1 (Sema) FDA approved?
The molecule is approved as a drug in specific clinical uses, but this listing is a research-use-only reference peptide and is not for human or veterinary use.
What is its molecular weight and CAS number?
GLP-1 (Sema) has a molecular weight around 4113.6 g/mol, the formula C187H291N45O59, and CAS number 910463-68-2.
How should the 10 mg vial be handled?
Keep it frozen at -20°C and out of light. After reconstitution for research, refrigerate at 2-8°C, use within about two weeks, and avoid repeated freeze-thaw cycles.
How pure is this GLP-1 (Sema)?
It is supplied at ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation from an independent lab, and a certificate of analysis comes with each batch.
Why does GLP-1 (Sema) need careful reconstitution?
Its large, modified structure dissolves best with gentle handling. Swirling rather than shaking and giving it time to go into solution helps keep the peptide intact.
