CAS: 218949-48-5 · MW: 5135.9 Da · Purity: ≥99% by reverse-phase HPLC · Format: 2 mg powder · Identity: ESI-MS confirmed
Tesamorelin is a longer, sturdier cousin of the body’s own growth-hormone-releasing hormone. It copies GHRH almost exactly, then adds a small chemical cap that keeps enzymes from chewing it up as fast, so it holds its shape longer in an experiment. This is the 2 mg vial, a size suited to smaller-scale work. Researchers use it to study the top of the growth-hormone axis, where GHRH tells the pituitary to release growth hormone.
Structure & Identity
Tesamorelin is a 44-amino-acid peptide, the full length of natural GHRH(1-44), with one deliberate modification: a trans-3-hexenoic acid group attached at the front end. That added group is the stabilizer. Everything else mirrors the natural hormone, which is why tesamorelin behaves as a faithful but longer-lasting stand-in for GHRH in research.
Research Background
Tesamorelin research sits at the GHRH receptor and the growth-hormone/IGF-1 signaling it drives.
- Stabilized GHRH. Tesamorelin is a full-length GHRH analog with an N-terminal cap that extends its active life [PMID: 20554713].
- Receptor target. It engages the GHRH receptor, the same receptor as natural GHRH [PMID: 19243281].
- GH/IGF-1 readouts. Downstream effects on the GH/IGF-1 axis have been tracked through metabolic endpoints [PMID: 24178787].
- Fat-quality research. It has been studied for effects on fat quality independent of fat quantity [PMID: 33756511].
- Analytical detection. Its structure has been characterized in work on detecting GHRH-type analogs [PMID: 34665524].
These are research contexts. Tesamorelin carries no approved use in this setting, and the material is intended for laboratory study only.
Specifications
| Attribute |
Value |
| Chemical name |
Tesamorelin (GHRH(1-44) analog) |
| Also Known As |
TH9507, GHRH(1-44) analog |
| Modification |
trans-3-hexenoic acid, N-terminal |
| CAS number |
218949-48-5 |
| Molecular formula |
C221H366N72O67S (confirm) |
| Molecular weight |
5135.9 g/mol |
| Purity |
≥99% by reverse-phase HPLC |
| Length |
44 amino acids |
| Identity |
Confirmed by ESI mass spectrometry |
| Physical form |
Lyophilized powder |
| Appearance |
White to off-white solid |
| Quantity |
2 mg per vial |
| Storage |
-20°C, protected from light |
| Solubility |
Soluble in bacteriostatic or sterile water (gentle mixing) |
| Classification |
Research use only |
Storage & Handling
Keep the sealed vial frozen at -20°C and shielded from light until you use it. After reconstitution, the solution should go into the fridge at 2-8°C and be used within about two weeks. As tesamorelin is a large peptide, it pays to warm the vial to room temperature before opening and to avoid freezing and thawing it repeatedly, both of which help the long chain stay intact.
Storage and Handling Guide
Quality Assurance
Tesamorelin is produced under research-grade manufacturing controls and released only after an outside lab signs off. Purity is measured by reverse-phase HPLC and identity by mass spectrometry, and that testing is done by independent third-party laboratories, including Janoshik Analytical and domestic US labs. The certificate of analysis is specific to each batch, so its figures match the vial you receive.
Quality & Testing
Frequently Asked Questions
What is tesamorelin?
Tesamorelin is a synthetic, stabilized version of growth-hormone-releasing hormone (GHRH). It is studied in laboratory research on the GHRH receptor and the growth-hormone/IGF-1 axis, and it is supplied for research use only.
How is tesamorelin different from regular GHRH?
It has the same 44-amino-acid sequence as GHRH but adds a trans-3-hexenoic acid cap that slows its breakdown. That small change lets it stay active longer in an experiment than natural GHRH would.
How does tesamorelin compare with CJC-1295?
Both are GHRH analogs that act at the GHRH receptor, but they are built differently. Tesamorelin is the full 44-residue GHRH with a stabilizing cap; CJC-1295 is a shorter modified GRF fragment. Researchers study each to compare GHRH-axis activity.
What is tesamorelin’s molecular weight?
It is a large peptide with a molecular weight around 5135.9 g/mol and CAS number 218949-48-5.
Is tesamorelin FDA approved?
The tesamorelin molecule is approved as a drug in a specific clinical context, but the material sold here is a research-use-only peptide, not for human or veterinary use.
Why choose the 2 mg size?
The 2 mg vial suits smaller-scale or exploratory research where less material is needed. The amount refers to the tesamorelin peptide content.
How should tesamorelin be stored?
Store the powder frozen at -20°C, protected from light. Once reconstituted for research, keep it at 2-8°C and use within about two weeks.
How is this tesamorelin verified?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch has its own published certificate of analysis.
References
- Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog. 2010. PMID: 20554713.
- The effects of tesamorelin on phosphocreatine recovery in subjects with reduced GH. 2014. PMID: 24178787.
- Advances in the detection of growth hormone releasing hormone synthetic analogs. 2021. PMID: 34665524.
