Description
Structure & Identity
GLP-2 (Tirz) is a synthetic 39-amino-acid peptide engineered as a dual agonist. Its sequence is based on the GIP peptide but tuned so that it activates both the GIP and GLP-1 receptors, and like GLP-1 (Sema) it carries a fatty-acid chain that binds albumin to extend its active life. That dual-receptor design is the defining feature researchers study.
Research Background
GLP-2 (Tirz) research is about dual incretin signaling, GIP and GLP-1 together.
- Dual-agonist characterization. Its original description introduced it as a novel dual GIP and GLP-1 receptor agonist, the foundation of the research interest [1].
- Biased signaling. Detailed pharmacology has described GLP-2 (Tirz) as an imbalanced, biased agonist across the two receptors, a nuance researchers actively study [2].
- GIP-plus-GLP-1 rationale. Work on why adding GIP to GLP-1 matters has helped frame the dual-receptor approach [3].
These are research contexts rather than approved uses, and the peptide is intended for laboratory study.
Specifications
| Attribute | Value |
| Chemical name | GLP-2 (Tirz) |
| Also Known As | (dual GIP/GLP-1 receptor agonist) |
| CAS number | 2023788-19-2 |
| Molecular formula | C225H348N48O68 |
| Molecular weight | 4813.5 g/mol |
| Length | 39 amino acids |
| Purity | ≥99% by reverse-phase HPLC |
| Length | 39 amino acids |
| Identity | Confirmed by ESI mass spectrometry |
| Physical form | Lyophilized powder |
| Appearance | White to off-white solid |
| Quantity | 15 mg per vial |
| Storage | -20°C, protected from light |
| Solubility | Soluble in bacteriostatic or sterile water (gentle mixing) |
| Classification | Research use only |
Storage & Handling
Store the sealed vial frozen at -20°C and shielded from light until use. After reconstitution, keep the solution refrigerated at 2-8°C and use it within about two weeks. As a large modified peptide, GLP-2 (Tirz) benefits from being warmed to room temperature before opening and from being aliquoted so it is not frozen and thawed repeatedly.
Quality Assurance
GLP-2 (Tirz) is produced under research-grade manufacturing controls and released only after independent verification. Purity is measured by reverse-phase HPLC and identity by mass spectrometry, with that work done by third-party laboratories such as Janoshik Analytical along with domestic US labs. A certificate of analysis is issued for each batch, so the results trace to the exact vial you receive.
Frequently Asked Questions
What is GLP-2 (Tirz)?
GLP-2 (Tirz) is a synthetic peptide that acts as a dual agonist at the GIP and GLP-1 receptors, the two main incretin pathways. It is studied in metabolic and receptor research and is supplied for research use only.
What is a “dual agonist”?
It means one molecule that switches on two different receptors. GLP-2 (Tirz) activates both the GIP receptor and the GLP-1 receptor, whereas single agonists like GLP-1 (Sema) activate only one.
How is GLP-2 (Tirz) different from GLP-1 (Sema)?
GLP-1 (Sema) targets the GLP-1 receptor alone; GLP-2 (Tirz) targets both GIP and GLP-1. That extra GIP activity is the main structural and pharmacological difference between the two.
What are GIP and GLP-1?
They are incretin hormones the gut releases after eating, both involved in metabolic signaling. GLP-2 (Tirz) is designed to act on the receptors for both.
Is GLP-2 (Tirz) FDA approved?
The GLP-2 (Tirz) molecule is approved as a drug in defined clinical uses, but this listing is a research-use-only reference peptide, not for human or veterinary use.
What is GLP-2 (Tirz)’s molecular weight?
It is a 39-amino-acid peptide with the formula C225H348N48O68, a molecular weight around 4813.5 g/mol, and CAS number 2023788-19-2.
How should GLP-2 (Tirz) be stored?
Keep the powder frozen at -20°C and protected from light. After reconstitution for research, store at 2-8°C and use within about two weeks.
How is this GLP-2 (Tirz) verified?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation by an independent lab, and each batch ships with a certificate of analysis.
