Description
Structure & Identity
GLP-2 (Tirz) is a 39-amino-acid peptide whose sequence, based on GIP, is tuned to activate both the GIP and GLP-1 receptors. A fatty-acid chain attached to the backbone binds albumin and extends its active life, much as in GLP-1 (Sema). What makes GLP-2 (Tirz) distinctive is not that stabilizer but its ability to engage two incretin receptors from one molecule.
Research Background
Research on GLP-2 (Tirz) focuses on how simultaneous GIP and GLP-1 signaling plays out.
- Dual agonist. Tirzepatide is engineered to activate both the GIP and GLP-1 receptors from one molecule [PMID: 30473097].
- Foundational profile. Its original characterization introduced it as a novel dual GIP/GLP-1 agonist [PMID: 30473097].
- Biased signaling. Pharmacology describes it as an imbalanced, biased agonist across the two receptors [PMID: 32730231].
- GIP rationale. Research clarifies how adding GIP may enhance GLP-1 signaling [PMID: 32396843].
- Comparative studies. It has been compared with semaglutide in metabolic research [PMID: 38613667].
These are laboratory research areas, not approved uses, and the peptide is provided for that study.
Specifications
| Attribute | Value |
| Chemical name | GLP-2 (Tirz) |
| Also Known As | (dual GIP/GLP-1 receptor agonist) |
| CAS number | 2023788-19-2 |
| Molecular formula | C225H348N48O68 |
| Molecular weight | 4813.5 g/mol |
| Length | 39 amino acids |
| Purity | ≥99% by reverse-phase HPLC |
| Identity | Confirmed by ESI mass spectrometry |
| Physical form | Lyophilized powder |
| Appearance | White to off-white solid |
| Quantity | 30 mg per vial |
| Storage | -20°C, protected from light |
| Solubility | Soluble in bacteriostatic or sterile water (gentle mixing) |
| Classification | Research use only |
Storage & Handling
Keep the unopened vial at -20°C, away from light, until needed. After you reconstitute it, store the solution at 2-8°C and use within roughly two weeks. Because this is a large peptide supplied in a sizable 30 mg quantity, dividing the reconstituted stock into aliquots is strongly worthwhile, and the vial should reach room temperature before opening.
Quality Assurance
Every lot of GLP-2 (Tirz) clears independent quality control before it ships. Manufacturing follows research-grade standards, and purity by reverse-phase HPLC and identity by mass spectrometry are confirmed by outside laboratories, including Janoshik Analytical and US-based labs. A batch-matched certificate of analysis travels with the vial, connecting the data to your material.
Frequently Asked Questions
What is the GLP-2 (Tirz) 30 mg for?
It is a research-use-only dual GIP/GLP-1 receptor agonist supplied in a large size for research programs that need more material. It has no approved human use in this setting.
Is the 30 mg the same molecule as the 15 mg?
Yes. The only difference is quantity. The 30 mg vial is for larger-scale or higher-throughput research.
Why is GLP-2 (Tirz) called a dual agonist?
Because one molecule activates two receptors, GIP and GLP-1, rather than just one. That dual action is the central research feature.
How does GLP-2 (Tirz) differ from GLP-1 (Sema)?
GLP-2 (Tirz) hits both the GIP and GLP-1 receptors; GLP-1 (Sema) hits only GLP-1. The added GIP activity is what distinguishes the two.
Is GLP-2 (Tirz) FDA approved?
The molecule is approved as a drug in defined clinical uses, but the material here is a research-use-only reference peptide and is not for human or veterinary use.
What are the molecular details?
GLP-2 (Tirz) is a 39-residue peptide, formula C225H348N48O68, molecular weight about 4813.5 g/mol, CAS number 2023788-19-2.
How should the 30 mg vial be handled?
Freeze at -20°C, protected from light. After reconstitution for research, aliquot, refrigerate at 2-8°C, and use within about two weeks to limit freeze-thaw cycles.
How is quality verified on the larger vial?
The same standard applies to every size: ≥99% purity by reverse-phase HPLC, mass-spec identity confirmation by an independent lab, and a certificate of analysis per batch.
