Description
Structure & Identity
Ipamorelin is a pentapeptide, a five-amino-acid chain with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. Two of those building blocks are unusual on purpose: Aib and the D-form amino acids are not the standard ones cells use, and they are what make the peptide resist quick breakdown while locking it onto its target receptor. The amidated (-NH2) end is another stabilizing touch.
Research Background
Ipamorelin was introduced in the late 1990s as the first genuinely selective growth-hormone secretagogue, and that selectivity is still its defining research feature [1].
- Selective secretagogue. Ipamorelin was introduced as the first genuinely selective growth-hormone secretagogue, releasing GH while largely sparing other pituitary hormones [PMID: 9849822].
- Receptor target. It acts at the ghrelin/GHS-R1a receptor, and its selectivity there is what made it a reference compound for that receptor [PMID: 39043357].
- Downstream readouts. In rat studies it was linked to longitudinal bone growth, giving a measurable marker of its activity [PMID: 10373343].
- Pharmacokinetics. Its behavior over time has been modeled in detail, helping labs design reproducible experiments [PMID: 10496658].
- Endocrine-axis research. It has been studied in the context of the hypothalamic-pituitary-testicular axis [PMID: 38996787].
These findings map an active research subject. None of them describe an approved use, and the material is intended purely to support further laboratory study.
Specifications
| Attribute | Value |
| Chemical name | Ipamorelin |
| Also Known As | NNC 26-0161 |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| CAS number | 170851-70-4 |
| Molecular formula | C38H49N9O5 |
| Molecular weight | 711.9 g/mol |
| Length | 5 amino acids |
| Purity | ≥99% by reverse-phase HPLC |
| Identity | Confirmed by ESI mass spectrometry |
| Physical form | Lyophilized powder |
| Appearance | White to off-white solid |
| Quantity | 10 mg per vial |
| Storage | -20°C, protected from light |
| Solubility | Soluble in bacteriostatic or sterile water |
| Classification | Research use only |
Storage & Handling
Store the sealed vial in a freezer at -20°C, shielded from light, until it is needed. After preparation, the working solution belongs in the fridge at 2-8°C and should be used for research within roughly two weeks. Warming a frozen vial to room temperature before you open it keeps condensation from forming inside, and limiting how often the material is frozen and thawed protects the peptide.
Quality Assurance
Ipamorelin is made under research-grade manufacturing controls and is not released until an outside lab has checked it. Purity is measured by reverse-phase HPLC and identity is confirmed by mass spectrometry, with that analysis handled by independent third-party laboratories, including Janoshik Analytical and domestic US labs. The certificate of analysis is tied to the specific batch, so the figures on it belong to the vial you receive.
Frequently Asked Questions
What is ipamorelin?
Ipamorelin is a synthetic five-amino-acid peptide that acts as a selective growth-hormone secretagogue, meaning it prompts growth-hormone signaling at one specific receptor. It is studied in laboratory research on the growth-hormone axis and is supplied for research use only.
Why is ipamorelin called “selective”?
Because it stimulates growth-hormone release without strongly triggering other pituitary hormones the way older secretagogues do. That narrow action is what made it a useful reference compound for researchers.
How does ipamorelin differ from CJC-1295?
They work through different receptors. Ipamorelin acts at the ghrelin/GHS-R1a receptor, while CJC-1295 is a GHRH analog that acts at the GHRH receptor. Researchers sometimes study them together because they hit the growth-hormone pathway from two angles.
What is ipamorelin’s sequence and molecular weight?
Its sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH2, its molecular formula is C38H49N9O5, and its molecular weight is about 711.9 g/mol.
Is ipamorelin FDA approved?
No, Ipamorelin is not an FDA-approved drug or a dietary supplement. It is a research-use-only material, not intended for human or veterinary use.
How should ipamorelin be stored?
Keep the dry powder frozen at -20°C and out of the light. Once it is reconstituted for research, store the solution at 2-8°C and use it within about two weeks.
How is the purity of this ipamorelin confirmed?
It is tested to ≥99% purity by reverse-phase HPLC with mass-spec identity confirmation, all done by independent third-party labs, and each batch has its own published certificate of analysis.
What does the 10 mg refer to?
It is the amount of ipamorelin peptide in the vial, supplied as lyophilized powder for reconstitution in a research setting.
References
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. 1998. PMID: 9849822.
- Svensson J, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. 1999. PMID: 10373343.
- Gobburu JV, et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide. 1999. PMID: 10496658.
Reviews
There are no reviews yet.